BackgroundThe foundation of health and medical research is data. Data sharing facilitates the progress of research and strengthens science. Data sharing in research is widely discussed in the literature; however, there are seemingly no evidence-based incentives that promote data sharing.MethodsA systematic review of the health and medical research literature was used to uncover any evidence-based incentives, with pre- and post-empirical data that examined data sharing rates. We were also interested in quantifying and classifying the number of opinion pieces on the (...) importance of incentives, the number observational studies that analysed data sharing rates and practices, and strategies aimed at increasing data sharing rates.ResultsOnly one incentive has been tested in health and medical research that examined data sharing rates. The number of opinion pieces out-weighed the number of article-testing strategies, and the number of observational studies exceeded them both.ConclusionsGiven that data is the foundation of evidence-based health and medical research, it is paradoxical that there is only one evidence-based incentive to promote data sharing. More well-designed studies are needed in order to increase the currently low rates of data sharing. (shrink)

We explored the neural mechanisms allowing humans to report the subjective onset times of conscious events. Magnetoencephalographic recordings of neural oscillations were obtained while human subjects introspected the timing of sensory, intentional, and motor events during a forced choice task. Brain activity was reconstructed with high spatio-temporal resolution. Event-time introspection was associated with specific neural activity at the time of subjective event onset which was spatially distinct from activity induced by the event itself. Different brain regions were selectively recruited for (...) introspection of different event types, e.g., the bilateral angular gyrus for introspection of intention. Our results suggest that event-time introspection engages specific neural networks to assess the contents of consciousness. Subjective event times should therefore be interpreted as the result of complex interactions between introspection and experience networks, rather than as direct reproduction of the individual’s conscious state or as a mere post hoc interpretation. (shrink)

BackgroundMulti-centre studies generally cost more than single-centre studies because of larger sample sizes and the need for multiple ethical approvals. Multi-centre studies include clinical trials, clinical quality registries, observational studies and implementation studies. We examined the costs of two large Australian multi-centre studies in obtaining ethical and site-specific approvals.MethodsWe collected data on staff time spent on approvals and expressed the overall cost as a percent of the total budget.ResultsThe total costs of gaining approval were 38 % of the budget for (...) a study of 50 centres (mean cost AUD $6960 per site) and 2 % for a study of 11 centres (mean cost AUD $2300 per site). Seventy-five and 90 % of time was spent on repeated tasks, respectively, and many time-consuming tasks, such as reformatting documents, did nothing to improve the study design or participant safety.ConclusionsImprovements have been made to the ethical approval application system, but more gains could be made without increasing risks of harm to research participants. We propose that ethical review bodies and individual sites publish statistics on how long they take to process approvals which could then be nationally benchmarked. (shrink)

BackgroundWinning funding for health and medical research usually involves a lengthy application process. With success rates under 20%, much of the time spent by 80% of applicants could have been better used on actual research. An alternative funding system that could save time is using democracy to award the most deserving researchers based on votes from the research community. We aimed to pilot how such a system could work and examine some potential biases.MethodsWe used an online survey with a convenience (...) sample of Australian researchers. Researchers were asked to name the 10 scientists currently working in Australia that they thought most deserved funding for future research. For comparison, we used recent winners from large national fellowship schemes that used traditional peer review.ResultsVoting took a median of 5 min (inter-quartile range 3 to 10 min). Extrapolating to a national voting scheme, we estimate 599 working days of voting time (95% CI 490 to 728), compared with 827 working days for the current peer review system for fellowships. The gender ratio in the votes was a more equal 45:55 (female to male) compared with 34:66 in recent fellowship winners, although this could be explained by Simpson’s paradox. Voters were biased towards their own institution, with an additional 1.6 votes per ballot (inter-quartile range 0.8 to 2.2) above the expected number. Respondents raised many concerns about the idea of using democracy to fund research, including vote rigging, lobbying and it becoming a popularity contest.ConclusionsThis is a preliminary study of using voting that does not investigate many of the concerns about how a voting system would work. We were able to show that voting would take less time than traditional peer review and would spread the workload over many more reviewers. Further studies of alternative funding systems are needed as well as a wide discussion with the research community about potential changes. (shrink)

The proliferation of mitochondrial DNA (mtDNA) with deletion mutations has been linked to aging and age related neurodegenerative conditions. In this study we model the effect of mtDNA half-life on mtDNA competition and selection. It has been proposed that mutation deletions (mtDNAdel\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\text {mtDNA}_{del}$$\end{document}) have a replicative advantage over wild-type (mtDNAwild\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\text {mtDNA}_{wild}$$\end{document}) and that this is detrimental to the host cell, especially in post-mitotic (...) cells. An individual cell can be viewed as forming a closed ecosystem containing a large population of independently replicating mtDNA. Within this enclosed environment a selfishly replicating mtDNAdel\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\text {mtDNA}_{del}$$\end{document} would compete with the mtDNAwild\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\text {mtDNA}_{wild}$$\end{document} for space and resources to the detriment of the host cell. In this paper, we use a computer simulation to model cell survival in an environment where mtDNAwild\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\text {mtDNA}_{wild}$$\end{document} compete with mtDNAdel\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\text {mtDNA}_{del}$$\end{document} such that the cell expires upon mtDNAwild\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\text {mtDNA}_{wild}$$\end{document} extinction. We focus on the survival time for long lived post-mitotic cells, such as neurons. We confirm previous observations that mtDNAdel\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\text {mtDNA}_{del}$$\end{document} do have a replicative advantage over mtDNAwild\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\text {mtDNA}_{wild}$$\end{document}. As expected, cell survival times diminished with increased mutation probabilities, however, the relationship between survival time and mutation rate was non-linear, that is, a ten-fold increase in mutation probability only halved the survival time. The results of our model also showed that a modest increase in half-life had a profound affect on extending cell survival time, thereby, mitigating the replicative advantage of mtDNAdel\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\text {mtDNA}_{del}$$\end{document}. Given the relevance of mitochondrial dysfunction to various neurodegenerative conditions, we propose that therapies to increase mtDNA half-life could significantly delay their onset. (shrink)

A working hypothesis of computationalism is that Mind arises, not from the intrinsic nature of the causal properties of particular forms of matter, but from the organization of matter. If this hypothesis is correct, then a wide range of physical systems (e.g. optical, chemical, various hybrids, etc.) should support Mind, especially computers, since they have the capability to create/manipulate organizations of bits of arbitrarily complexity and dynamics. In any particular computer, these bit patterns are quite physical, but their particular physicality (...) is considered irrelevant (since they could be replaced by other physical substrata). (shrink)

Goswami proposes to replace the current scientific paradigm of physical realism with that of a quantum-based monistic idealism and, in the process, accomplish the following goals: establish a basis for explaining consciousness, reintegrate spirituality, mysticism, morality, a sense that the universe is meaningful, etc., with scientific discoveries and the scientific enterprise, and support the assumption that humans possess free will - i.e., that they are not controlled by the apparently inexorable causality of the physical laws that govern the functioning of (...) their brains. Here, we critically examine this approach, from an artificial intelligence and neural network perspective, and point out what appear to be some inherent weaknesses in Goswami's arguments. (shrink)

The neural blackboard architecture is a localist structured connectionist model that employs a novel connection matrix to implement dynamic bindings without requiring propagation of temporal synchrony. Here I note the apparent need for many distinct matrices and the effect this might have for scale-up to semantic processing. I also comment on the authors' initial foray into the symbol grounding problem.

Shastri & Ajjanagadde argue convincingly that both structured connectionist networks and parallel dynamic inferencing are necessary for reflexive reasoning - a kind of inferencing and reasoning that occurs rapidly, spontaneously, and without conscious effort, and which seems necessary for everyday tasks such as natural language understanding. As S&A describe, reflexive reasoning requires a solution to thedynamic binding problem, that is, how to encode systematic and abstract knowledge and instantiate it in specific situations to draw appropriate inferences. Although symbolic artificial intelligence (...) systems trivially solve the dynamic binding problem using computers' registers and pointers, it has remained a difficult problem for connectionist systems. S&A's temporal synchrony solution to the dynamic binding problem using synchronous firing of argument units and the entities that are bound to them illustrates one way in which connectionist networks can do thisusing a constrained but important class of long-term knowledge rules. Their structured connectionist solution allows dynamic inferencing to proceed in parallel and therefore has a number of advantages for reflexive reasoning over most other connectionist and symbolic systems. (shrink)

Inspired by the writings of J. M. Hinton (1967a, 1967b, 1973), but ushered into the mainstream by Paul Snowdon (1980–1, 1990–1), John McDowell (1982, 1986), and M. G. F. Martin (2002, 2004, 2006), disjunctivism is currently discussed, advocated, and opposed in the philosophy of perception, the theory of knowledge, the theory of practical reason, and the philosophy of action. But what is disjunctivism?

ObjectivesIndividuals register and react to daily sensory stimuli differently, which influences participation in occupations. Sleep is a foundational nightly occupation that impacts overall health and development in children. Emerging research suggests that certain sensory processing patterns, specifically sensory sensitivities, may have a negative impact on sleep health in children. In this study, we aimed to characterize sleep in children with and without sensory sensitivities and examine the relationship between sensory processing patterns and sleep using validated parent- and child-reported questionnaires. We (...) hypothesized that children with sensory sensitivities will exhibit more difficulties with sleep.MethodsWe recruited 22 children with sensory sensitivities and 33 children without sensory sensitivities to complete validated sleep and sensory processing questionnaires: the Children’s Sleep Habits Questionnaire, Sleep Self-Report, and Sensory Profile-2.ResultsChildren with SS had significantly more sleep behaviors reported by both parents and children compared to children with NSS. Specifically, children with SS had higher frequencies of sleep anxiety, bedtime resistance, and sleep onset delay. Spearman’s ρ correlations indicated significant positive correlations between parent- and child-reported sleep. Children with SS showed a larger association and greater variability between sleep and sensory processing compared to their peers. Significant positive correlations between parent-reported sleep behaviors and sensory sensitive and avoiding patterns were identified for both children with SS and NSS. Child-reported sleep behaviors were most strongly associated with sensitive and avoiding patterns for children with NSS and seeking patterns for children with SS.ConclusionWe present evidence that sleep is impacted for children with SS to a greater extent than children with NSS. We also identified that a child’s sensory processing pattern may be an important contributor to sleep problems in children with and without sensory sensitivities. Sleep concerns should be addressed within routine care for children with sensory sensitivities. Future studies will inform specific sleep intervention targets most salient for children with SS and other sensory processing patterns. (shrink)

Cognitive modeling is the effort to understand the mind by implementing theories of the mind in computer code, producing measures comparable to human behavior and mental activity. The community of cognitive modelers has traditionally met twice every 3 years at the International Conference on Cognitive Modeling. In this special issue of topiCS, we present the best papers from the ICCM meeting. These best papers represent advances in the state of the art in cognitive modeling. Since ICCM was for the first (...) time also held jointly with the Society for Mathematical Psychology, we use this preface to also reflect on the similarities and differences between mathematical psychology and cognitive modeling. (shrink)

In this issue of topiCS, we present the best papers from the ICCM meeting. These best papers represent advances in the state of the art in cognitive modeling. Since ICCM was for the first time also held jointly with the Society for Mathematical Psychology, we use this preface to also reflect on the similarities and differences between mathematical psychology and cognitive modeling.

Drawing on a landscape analysis of existing data-sharing initiatives, in-depth interviews with expert stakeholders, and public deliberations with community advisory panels across the U.S., we describe features of the evolving medical information commons. We identify participant-centricity and trustworthiness as the most important features of an MIC and discuss the implications for those seeking to create a sustainable, useful, and widely available collection of linked resources for research and other purposes.

With a history of 2000 years, the dialogue between Orthodoxy and Judaism experienced difficult times that have left deep scars in the hearts of the followers of the two religions. In the modern and contemporary period, without forgetting the past, it is trying to find bridges between the two religions with the purpose to help the faithful to respond responsibly to the challenges of the present and future. The themes that have been analyzed in the past are of a great (...) interest to our times: the relationship between the Old and New Testaments, the place and the role of the Bible in the two monotheistic traditions, Jerusalem as a Holy City, the religious freedom, the quality and the responsibility of elected people, the problem of religious freedom. Finally, only through sincere cooperation one can find relevant answers to the faithful of the both religions. (shrink)

Corruption involves greed, money, and risky decision-making. We explore the love of money, pay satisfaction, probability of risk, and dishonesty across cultures. Avaricious monetary aspiration breeds unethicality. Prospect theory frames decisions in the gains-losses domain and high-low probability. Pay dissatisfaction (in the losses domain) incites dishonesty in the name of justice at the individual level. The Corruption Perceptions Index, CPI, signals a high-low probability of getting caught for dishonesty at the country level. We theorize that decision-makers adopt avaricious love-of-money aspiration (...) as a lens and frame dishonesty in the gains-losses domain (pay satisfaction-dissatisfaction, Level 1) and high-low probability (CPI, Level 2) to maximize expected utility and ultimate serenity. We challenge the myth: Pay satisfaction mitigates dishonesty across nations consistently. Based on 6500 managers in 32 countries, our cross-level three-dimensional visualization offers the following discoveries. Under high aspiration conditions, pay dissatisfaction excites the highest- (third-highest) avaricious justice-seeking dishonesty in high (medium) CPI nations, supporting the certainty effect. However, pay satisfaction provokes the second-highest avaricious opportunity-seizing dishonesty in low CPI entities, sustaining the possibility effect—maximizing expected utility. Under low aspiration conditions, high pay satisfaction consistently leads to low dishonesty, demonstrating risk aversion—achieving ultimate serenity. We expand prospect theory from a micro and individual-level theory to a cross-level theory of monetary wisdom across 32 nations. We enhance the S-shaped Curve to three 3-D corruption surfaces across three levels of the global economic pyramid, providing novel insights into behavioral economics, business ethics, the environment, and responsibility. (shrink)

The paper argues that two distinct and independent notions of plurality are involved in natural language anaphora and quantification: plural reference (the usual non-atomic individuals) and plural discourse reference, i.e., reference to a quantificational dependency between sets of objects (e.g., atomic/non-atomic individuals) that is established and subsequently elaborated upon in discourse. Following van den Berg (PhD dissertation, University of Amsterdam, 1996), plural discourse reference is modeled as plural information states (i.e., as sets of variable assignments) in a new dynamic system (...) couched in classical type logic that extends Compositional DRT (Muskens, Linguistics and Philosophy, 19, 143-186, 1996). Given the underlying type logic, compositionality at sub-clausal level follows automatically and standard techniques from Montague semantics become available. The idea that plural info states are semantically necessary (in addition to non-atomic individuals) is motivated by relative-clause donkey sentences with multiple instances of singular donkey anaphora that have mixed (weak and strong) readings. At the same time, allowing for non-atomic individuals in addition to plural info states enables us to capture the intuitive parallels between singular and plural (donkey) anaphora, while deriving the incompatibility between singular (donkey) anaphora and collective predicates. The system also accounts for empirically unrelated phenomena, e.g., the uniqueness effects associated with singular (donkey) anaphora discussed in Kadmon (Linguistics and Philosophy, 13, 273-324, 1990) and Heim (Linguistics and Philosophy, 13, 131-177, 1990) among others. (shrink)

One of the insights of dynamic semantics in its various guises (Kamp 1981, Heim 1982, Groenendijk & Stokhof 1991, Kamp & Reyle 1993 among many others) is that interpretation is sensitive to left-to-right order. Is order sensitivity, particularly the default left-to-right order of evaluation, a property of particular meanings of certain lexical items (e.g., dynamically interpreted conjunction) or is it a more general feature of meaning composition? If it is a more general feature of meaning composition, is it a processing (...) ‘preference’ or should it be captured as a ‘harder’ constraint on the type of meanings and operations over meanings involved in natural language interpretation? This squib draws attention to the symmetrical A-too B-too construction (found in a variety of languages, e.g., Hungarian, Japanese, Romanian, Russian) in this context. It argues that any semantic analysis of its main ‘symmetrical-meaning’ characteristic should also allow for subtler interactions between this construction and items that are clearly sensitive to evaluation-order effects, e.g., anaphoric adjectives like next and other. We suggest that the notion of postsupposition embedded in a broader dynamic framework is better able to account for both the symmetric nature of this construction, its non-symmetric variant A-too, and its interaction with items that are evaluation-order sensitive. We briefly compare this proposal with a couple of possible alternative accounts. (shrink)

George McGhee’s book “Convergent Evolution: limited forms most beautiful” provides an extensive survey of biological convergence. This paper has two main aims. First, it examines the theoretical claims McGhee makes about convergent evolution—specifically criticizing his use of a total morphospace to understand contingency and his assumption that functional constraints are non-contingent. Second, it sketches a group of important conceptual challenges facing researchers interested in convergence.

This is a constructive critique of Habermas’s account of rationality, which is central to his political theory and has sparked theoretical and empirical research across academia. Habermas and many critical theorists caricature means-ends rationality, e.g. by wrongly depicting it as egocentric. This weakens Habermas’s attempt to distinguish means-ends rationality from his hugely important and influential idea of communicative rationality. I suggest that sincerity and autonomy, rather than non-egocentrism, are the key distinguishing features of communicative rationality. This shows that communicative rationality (...) actually overlaps with means-ends rationality. Indeed, means-ends rationality is needed by critical theorists, as I exemplify by showing its use in deliberative democracy. Moreover, means-ends rationality will be present in discourse ethics, as I show with the example of moral discourse about gay marriage. My article thus challenges decades of what Habermas and critical theorists have written on means-ends and communicative rationality, but I stay broadly true to – and hopefully improve – Habermas’s account of rationality. (shrink)

My modest aim in this paper is to prove certain relations between some type of hyper-intensional operators, namely context shifting operators, and compositionality in natural languages. Various authors (e.g. von Fintel & Matthewson 2008; Stalnaker 2014) have argued that context-shifting operators are incompatible with compositionality. In fact, some of them understand Kaplan’s (1989) famous ban on context-shifting operators as a constraint on compositionality. Others, (e.g. Rabern 2013) take contextshifting operators to be compatible with compositionality but, unfortunately, do not provide a (...) proof, or an argument in favor of their position. The aim of this paper is to do precisely that. Additionally, I provide a new proof that compositionality for propositional content (intension) is a proper generalization of compositionality for character (hyper-intensions). (shrink)

After severe brain injury, one of the key challenges for medical doctors is to determine the patient’s prognosis. Who will do well? Who will not do well? Physicians need to know this, and families need to do this too, to address choices regarding the continuation of life supporting therapies. However, current prognostication methods are insufficient to provide a reliable prognosis. -/- Functional Magnetic Resonance Imaging (MRI) holds considerable promise for improving the accuracy of prognosis in acute brain injury patients. Nonetheless, (...) research on functional MRI in the intensive care unit context is ethically challenging. These studies raise several ethical issues that have not been addressed so far. In this article, Prof. Charles Weijer and his co-workers provide a framework for researchers and ethics committees to design and review these studies in an ethically sound way. (shrink)

Although it might seem to elicit only a marginal interest for philosophical inquiry, in 20th century continental philosophy the experience of solitude and loneliness were shown to have unexpected importance and gravity. For philosophers such as M. Heidegger, H. Arendt, H.-G. Gadamer or P. Sloterdijk, solitude and loneliness are to be seen, on the one hand, as an ontological determination of our Being and, on the other, as a cause for some of the most worrisome problems of our times such, (...) as the birth of totalitarianism or the phenomenon of self-alienation wide-spread in the Western bureaucratic societies. But none of the philosophers dealing with these matters offers us a clear positive understanding of what solitude and loneliness actually are nor what the task of philosophy should be with regard to these experiences even though they give us to understand that philosophy has one. The present paper tarries upon this question, approaching it from the other end though an investigation of the status of alterity in Heidegger and Gadamer’s philosophy. (shrink)

Tailoring climate change messages to a particular spatial scale (e.g. a specific country or region) is often seen as an effective way to frame communication about climate change. Yet the empirical evidence for the effectiveness of this strategy is scarce, and little is known about how recipients react to spatially-framed climate change messages. To learn more about the effects and usefulness of different spatial frames as a communication and engagement tool, we conducted a study in which we presented members of (...) the general public with either a national or a global framing of climate change. In contrast to previous spatial-framing studies, the present research used semi-structured interviews - rather than survey questions - to obtain rich, in-depth information about participants' views of climate change. Irrespective of the framing, participants revealed associations that were located at various spatial scales. Moreover, when participants talked about climate change, they repeatedly switched between different spatial scales, revealing patterns that were consistent with seeking to preserve existing beliefs and preferences. These findings improve our understanding of how the public represents climate change, and provide a novel explanation as to why simple spatial framing often fails to achieve the anticipated effects. (shrink)